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filingDate 2013-09-23-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_eb139dde79e04400ce7cd9c110ec337a
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publicationDate 2015-08-06-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-2015218654-A1
titleOfInvention Methods for predicting multiple myeloma treatment response
abstract The present invention relates to a method of testing whether a patient suffering of multiple myeloma will respond or not to a DNA methyltransferase inhibitor (DNMTi) comprising: i. determining the expression level (ELi) of several genes G 1 -G n selected from table A in a biological sample obtained from said patient ii. comparing the expression level (ELi) determined at step i) with a predetermined reference level (ELRi) iii. calculating the DMS score trough the following formula (I) wherein β1 represent the regression β coefficient reference value for the gene G i and Ci=1 if the expression of the gene G i (ELi) is higher than the predetermined reference level (ELRi) or Ci=−1 if the expression of the gene (ELi) is lower than or equal to the predetermined reference level (ELRi) comparing the score DMS determined at step iii) with a predetermined reference value DMS R and concluding that the patient will respond to the DNMTi when the DMS score is higher than the predetermined reference value DMS R or concluding that the patient will not respond to the DNMTi when the DMS score is lower than the predetermined reference value DMS R . n n n n n n n n DMS n = n n n ∑ n n i n = n 1 n n n n n  n n β n  n n n n  n i n × n Ci n n n n n n n ( n I n )
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