Predicate |
Object |
assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_191053ceb37e0ff327ef39370d5d4626 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_6daca7f29ebd36bf83f24a9f6e533058 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_31db23cce2a82d61810e66e266d587ea |
classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02A90-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-158 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-106 |
classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-7068 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-706 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G06F19-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6886 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G16B25-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G16B25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G16H10-40 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G16H20-40 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G06F19-3456 |
classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G06F19-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-706 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G16B25-10 |
filingDate |
2013-09-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_eb139dde79e04400ce7cd9c110ec337a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_37404c71527e1e66d2fb43c37deb45b9 |
publicationDate |
2015-08-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber |
US-2015218654-A1 |
titleOfInvention |
Methods for predicting multiple myeloma treatment response |
abstract |
The present invention relates to a method of testing whether a patient suffering of multiple myeloma will respond or not to a DNA methyltransferase inhibitor (DNMTi) comprising: i. determining the expression level (ELi) of several genes G 1 -G n selected from table A in a biological sample obtained from said patient ii. comparing the expression level (ELi) determined at step i) with a predetermined reference level (ELRi) iii. calculating the DMS score trough the following formula (I) wherein β1 represent the regression β coefficient reference value for the gene G i and Ci=1 if the expression of the gene G i (ELi) is higher than the predetermined reference level (ELRi) or Ci=−1 if the expression of the gene (ELi) is lower than or equal to the predetermined reference level (ELRi) comparing the score DMS determined at step iii) with a predetermined reference value DMS R and concluding that the patient will respond to the DNMTi when the DMS score is higher than the predetermined reference value DMS R or concluding that the patient will not respond to the DNMTi when the DMS score is lower than the predetermined reference value DMS R . n n n n n n n n DMS n = n n n ∑ n n i n = n 1 n n n n n n n β n n n n n n i n × n Ci n n n n n n n ( n I n ) |
priorityDate |
2012-09-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type |
http://data.epo.org/linked-data/def/patent/Publication |