abstract |
Using a combination of Kumada, Suzuki and Biellmann chemistry, various menaquinones can synthesised rapidly and with stereochemical integrity offering a new way of preparing these vitamin K2 components for the pharmaceutical market. In one embodiment a process for the preparation of a compound of formula (I) n n n n n n n n n n n n is defined including a step in which (i) a compound of formula (II) is reacted with a compound of formula (III) n n n n n n n n n n n n n n n n wherein R is an alkyl group; n LG is a leaving group; n m is an integer from 0 to 8; n n is an integer of from 0 to 9; and n X is hydrogen, halide, hydroxyl or protected hydroxyl; n in the presence of a copper, nickel or palladium catalyst. |