Predicate |
Object |
assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_08a3a6ad3f21ac5177a32576c7f88c7a |
classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61M5-19 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-48215 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-65 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-60 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6903 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-553 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-26 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-48338 |
classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-553 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-26 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-48 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61M5-19 |
filingDate |
2015-03-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_eb3c2bac09f92d8be94e21469ede8249 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f1d893ffb3c06069710c6ec0460f0135 |
publicationDate |
2015-07-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber |
US-2015202317-A1 |
titleOfInvention |
Dipeptide-based prodrug linkers for aliphatic amine-containing drugs |
abstract |
The present invention relates to a prodrug or a pharmaceutically acceptable salt thereof, comprising a drug linker conjugate D-L, wherein D being a biologically active moiety containing an aliphatic amine group is conjugated to one or more polymeric carriers via dipeptide-containing linkers L. Such carrier-linked prodrugs achieve drug releases with therapeutically useful half-lives. The invention also relates to pharmaceutical compositions comprising said prodrugs and their use as medicaments. |
isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11471497-B1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-112920279-B http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-112557541-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11117946-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109369779-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2017162650-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109655557-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2018213377-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11607441-B2 |
priorityDate |
2010-01-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type |
http://data.epo.org/linked-data/def/patent/Publication |