| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_7e655f996c3d706ce7a8b9d89fb97c1b |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-91142
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2400-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-9125 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-573
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-48 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-573 |
| filingDate |
2013-08-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e73be8b70a7fc25fce4048fa69188e3f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5709ad1fbf071cbf7c575a0af8633323
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b5e52872c4dad768294b790a3522751c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b953f9e9cb82e71120dfe8ebd46463d3 |
| publicationDate |
2015-07-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2015198597-A1 |
| titleOfInvention |
Method for monitoring PARP activity in cells by PARP activation |
| abstract |
The current invention provides for improved methods for determining PAR, and uses thereof. These improved methods involve an incubation step at a low temperature, for example around, but above, the freezing point after a PARP activation step. This improves the assay's sensitivity in comparison to current assay's performance. For example, sensitivity can be improved in methods assaying cells obtained from subjects such as human patients. The current invention also allows to provide methods to screen compounds for modulating PARG and/or PARP activity. |
| priorityDate |
2012-08-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |