| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8381805eba6d034fc77bd230dd02e6e2 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-01
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2318-20 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-48484
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6829
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-164
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-1282
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-33
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-64
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-48246
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-47
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-78 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-48
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-47 |
| filingDate |
2013-06-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7af5a3588e27d4d534484819a5b5bf5f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_021e339546ef9153d2eb3679f9e897d6
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bf6e6072dae6f83118d3652c3e761a5d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1a66fe5dcefaf624e0f0a734483e5bca |
| publicationDate |
2015-06-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2015174265-A1 |
| titleOfInvention |
Reversible masking of pore-forming proteins for macromolecular delivery |
| abstract |
The present invention features compositions and methods for enhancing endosomal escape of therapeutic agents in the cytoplasm of a cell to thereby provide more effective therapy. The endocytic pathway is the major uptake mechanism of cells, and biological agents such as proteins, DNA, and siRNA become entrapped in endosomes and subsequently degraded by lysosomal enzymes. The present invention facilitates endosomal escape by providing fusion proteins with membrane disruptive activity. In some embodiments, the fusion protein has endosomolytic activity that is activated at endosomal or lysosomal pH. In other embodiments, the fusion protein has reversible and pH sensitive membrane disruptive activity so that once internalized into the endosomal or lysosomal compartments, the resulting reduction in pH causes the pH sensitive fusion protein to activate and disrupt the endosomal or lysosomal membrane. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11230580-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9636419-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2018346596-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2015190529-A1 |
| priorityDate |
2012-06-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |