| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_38f6403d850a1fe9e34ef7fd5a010318 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C2601-16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C2101-16 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C227-32
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F9-5045
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F15-0033
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C67-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C67-343
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C67-31
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C68-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C69-734
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D205-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C69-96
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D205-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C227-16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C227-18
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C229-34
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C229-30 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C227-18
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C227-16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C229-30
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C67-31
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D205-04 |
| filingDate |
2013-01-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_69ed4c9b5712ade4a6fa0f74dde84b57
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3dd0515aaad92fc2759df2860827a47a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f11631f7c40a1c18b1dc2a9a696efe87 |
| publicationDate |
2015-06-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2015166479-A1 |
| titleOfInvention |
Process for synthesis of ezetimibe and intermediates used in said process |
| abstract |
A process for the production of ezetimibe and intermediates used in said process are disclosed. A kind of Morita-Baylis-Hillman adduct can be altered to chiral carboxylic acid derivatives of β-arylamino α-methylene with high activity and selectivity by means of ally lamination reaction, and the above carboxylic acid derivatives of β-arylamino α-methylene can be altered to the chiral intermediates of ezetimibe by means of simple conversion and further synthesized into the chiral drug ezetimibe. The synthesis route introduces chirality through the use of a chiral catalysis method, thereby avoiding the use of the chiral auxiliary oxazolidinone; and the route is economical and eco-friendly. |
| priorityDate |
2012-07-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |