| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_716e9a2606ffd4ba1a2a3917e4a402fd
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c88ceb051520bb25da4c002e034b6fe7 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D277-20
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D277-36
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-495
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-496
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-437
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-695
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D213-83
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-426 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-496 |
| filingDate |
2013-06-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_27e6876409c8a383eb50296787722460
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_09572cb883450a4fd6211efbf91be00e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3928b29e5f5166eae06ff94212a7df5f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4bfae3b6c7bded101c7e47e56e2c904d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0ea72b32b93adf3363aa239736e1290f |
| publicationDate |
2015-05-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2015133467-A1 |
| titleOfInvention |
Screening method, protein instability and/or stability inducers, and protein activity assessment |
| abstract |
Provided is a screening method with which it is possible to determine the cause of a decrease or an increase in the amount of a target protein that is expressed by a cell. One or a plurality of embodiments include: conducting cultivation that includes bringing an assay cell into contact with a test substance, and measuring a relative amount (A) of the target protein in relation to an internal standard; conducting cultivation in which an assay cell is not brought into contact with a test substance, and measuring a relative amount (B) in relation to an internal standard; comparing the relative amount (A) and the relative amount (B); and, based on the comparison, selecting a candidate substance that induces instability and/or stability in the target protein. The assay cell is a cell that is able to express mRNA of the target protein and mRNA of the internal standard protein under the identical regulation of gene expression, or a cell having a means for expressing mRNA of the target protein and mRNA of the internal standard protein under the identical regulation of gene expression. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110055280-A |
| priorityDate |
2012-06-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |