Predicate |
Object |
assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a1cd7029ec038fa78d4b371f9bf08e9e http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_32d60cbc9dd090a3f5ccaee68d241feb http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5a3b693ea69157155c02d421095221c9 |
classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-505 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-506 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P13-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-16 |
classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-505 |
filingDate |
2014-10-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_38898b2111c926b8b3893f807102adce http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3bc6881e6cbaf6ca4e62ac83a839c65b |
publicationDate |
2015-04-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber |
US-2015119413-A1 |
titleOfInvention |
Treatment of polycystic diseases with an hdac6 inhibitor |
abstract |
An HDAC6-specific inhibitor (i.e., a compound of Formula I or II) is shown to reduce the pathogenesis associated with polycystic disease. Administration of an HDAC6-specific inhibitor attenuated many of the symptoms characteristic of polycystic liver disease including cyst formation, cyst growth and cholangiocyte proliferation. Treatment with a HDAC6-specific inhibitor also increased the amount of bile duct acetylated tubulin and β-catenin phosphorylation and/or acetylation while reducing bile duct β-catenin synthesis. These results demonstrate that HDAC6 is overexpressed in cystic cholangiocytes and that its pharmacological inhibition reduces cholangiocyte proliferation and cyst growth. |
isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10144714-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10464906-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11324744-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2015239869-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10722512-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2018039581-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9957259-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9884850-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9949972-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9464073-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111902140-A |
priorityDate |
2013-10-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type |
http://data.epo.org/linked-data/def/patent/Publication |