http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2015119388-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d4c1f719c4c47e6fb95bcbcacee94784 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_588f4799eeda38576f3d4784cef85ded |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-365 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-55 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-5377 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-554 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4745 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-365 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-5377 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4745 |
| filingDate | 2013-06-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_17e483cdff784199cfb92a3496e872c4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_260866a908f5bef0a81089edd9d6dbf5 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_66e1b9ddbd2094bdf22750f689a4cb79 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1e5d7fcdd2e3604dbd14125a9656a8eb |
| publicationDate | 2015-04-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-2015119388-A1 |
| titleOfInvention | Novel pro- and codrug derivatives for nanoparticle delivery of select anticancer agents formed using rapidly cleavable phenolic ester bridges |
| abstract | An ester of ArOH according to the formula R—X—CO—OAr, wherein ArOH is a pharmaceutically active compound selected from the group consisting of SN-38, PI-103, etoposide and fenretinide, wherein a) R is a residue of cholesterol, sitosterol, SN-38, PI-103, etoposide or fenretinide and X is O—CO-L, wherein L is either a direct bond or a linking group including a branched or unbranched hydrocarbyl moiety that may optionally include in-chain or pendant heteroatom substituents and/or cyclic moieties; b) R—X—CO-0 is an all-trans retinoate radical or the 9-cis or 13-cis isomer thereof; or c) R—X— is a branched or unbranched, saturated or unsaturated hydrocarbyl moiety comprising at least 5 carbon atoms and optionally including at least one in-chain or pendant heteroatom substituent and/or cyclic moiety. A dispersion of nanoparticles in an aqueous medium includes nanoparticles including an ester of ArOH according to the formula R—X—CO—OAr wherein ArOH is a pharmaceutically active compound in which Ar is a substituted or unsubstituted aryl or heteroaryl radical, and wherein R is as defined above or R—X—CO-0 is as defined above. The ester or dispersion may be used to treat a diagnosed medical condition in a patient. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11633485-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10463743-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2018169934-A1 |
| priorityDate | 2012-06-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 181.