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filingDate 2014-09-25-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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publicationDate 2015-04-23-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-2015108369-A1
titleOfInvention Single particle detection device, single particle detection method, and computer program for single particle detection, using optical analysis
abstract There is provided a single particle detection technique based on the scanning molecule counting method which individually detects single particles using light measurement with a confocal or multiphoton microscope, where the existences of a non-light-emitting particle and a light-emitting particle can be detected while being discriminated from one another in a sample solution. The inventive technique of detecting a single particle detects light from a light detection region during moving the position of the light detection region of the microscope in a sample solution containing a non-light-emitting particle and a light-emitting particle to generate time series light intensity data; and detects in the time series light intensity data a light intensity increase relative to background light intensity as a signal indicating the existence of the light-emitting particle and a light intensity reduction relative to the background light intensity as a signal indicating the existence of the non-light-emitting particle.
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