| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8e071d18fea054bf8d1420d483e78ed1
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_01a96e8bbea00eeaa0b50c2a0c000dba |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2503-02 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K45-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-085
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-165
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-167
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P23-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-6872
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-0014 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-167
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-00 |
| filingDate |
2014-09-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_04d00f24121d978d863eedc2f3a1c1d8
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6bfc8699bc94234771359230becf3ab6 |
| publicationDate |
2015-03-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2015087714-A1 |
| titleOfInvention |
Methods, compositions, and kits for treating pain and pruritis |
| abstract |
The invention features a method for inhibiting one or more voltage-gated ion channels in a cell by contacting the cell with (i) a first compound that activates a channel-forming receptor that is present on nociceptors and/or pruriceptors; and (ii) a second compound that inhibits one or more voltage-gated ion channels when applied to the internal face of the channels but does not substantially inhibit said channels when applied to the external face of the channels, wherein the second compound is capable of entering nociceptors or pruriceptors through the channel-forming receptor when the receptor is activated. The invention also features a quaternary amine derivative or other permanently or transiently charged derivative of a compound that inhibits one or more voltage-gated ion channels when applied to the internal face of the channels but does not substantially inhibit said channels when applied to the external face of the channels. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11643404-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10780083-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10786485-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11512058-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11377422-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11332446-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11021443-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10927096-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10933055-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10934263-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10968179-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2022099284-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10842798-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10828287-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11696912-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11603355-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10729664-B2 |
| priorityDate |
2006-11-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |