http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2015051839-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_9d741545821f59e00db3be1bfb440240 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2800-22 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G06F19-3431 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-6857 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G16H50-30 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G06F19-00 |
| filingDate | 2013-03-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7df697645647faf4d1ea4ade7fc7f6ac http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dcbe479a9960088e45e8b76af930bf3c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_29689ae0d49bb8db2307300b2592df4d |
| publicationDate | 2015-02-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-2015051839-A1 |
| titleOfInvention | Method for characterising plasma cell associated diseases |
| abstract | The invention provides a method for characterising a plasma cell associated disease in a patient comprising: (i) providing at least one sample from the patient; (ii) determining in the sample(s) two or more of; (a) the κ:λ free light chain (FLC) ratio; (b) the ratio of κ light chains bound to a class of heavy chain:λ light chain bound to the same class of heavy chain (HLCκ:HLC λ ratio); (c) the total amount of FLC in the samples and (d) the total amount of κ light chains bound to the heavy chain class plus λ light chains bound to the same heavy chain class (total HLC); (iii) comparing each ratio or amount from (a) (b), (c) and/or (d) to predetermined values and assigning a score to each amount or ratio; and (iv) using the scores to characterise the plasma cell associated disease. Apparatus configured to carry out the method of the invention are also provided. The invention also provides a kit comprising, in combination, (i) anti-κ FLC specific and anti-λ FLC specific antibodies or fragments thereof and (ii) anti-κ heavy chain class specific and anti-λ heavy chain class specific antibodies or fragments thereof, optionally mixed together. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11604196-B2 |
| priorityDate | 2012-03-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 68.