http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2015051474-A1

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publicationDate 2015-02-19-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-2015051474-A1
titleOfInvention Mr imaging using apt contrast enhancement and sampling at multple echo times
abstract The invention relates to a method of CEST or APT MR imaging of at least a portion of a body ( 10 ) placed in a main magnetic field B 0 within the examination volume of a MR device. The method of the invention comprises the following steps: •a) subjecting the portion of the body ( 10 ) to a saturation RF pulse at a saturation frequency offset; •b) subjecting the portion of the body ( 10 ) to an imaging sequence comprising at least one excitation/refocusing RF pulse and switched magnetic field gradients, whereby MR signals are acquired from the portion of the body ( 10 ) as spin echo signals; •c) repeating steps a) and b) two or more times, wherein the saturation frequency offset and/or a echo time shift in the imaging sequence are varied, such that a different combination of saturation frequency offset and echo time shift is applied in two or more of the repetitions; •d) reconstructing a MR image and/or B 0 field homogeneity corrected APT/CEST images from the acquired MR signals. Moreover, the invention relates to a MR device ( 1 ) for carrying out the method of the invention and to a computer program to be run on a MR device.
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