| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_18d92c46f60af8af24e262b67381d7eb |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-112
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-156 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6886 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-68 |
| filingDate |
2014-08-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8df4601275b6663c6c716ed36907b511
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e421a40bb6560bfd11074ed78df15353
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_60c40e420404593e6d184301f5c2655d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a706926c5c3cb30b022a6c04d4365bda
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5f32541d928800624df5eb50132d09da
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_edeb61f3d331d68f352a3c1490df2916
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2e96b32a8339c7bbd281979bd8cb72f5
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5fcf64f99ed1b82104f1a38bd69697d6
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bcdcdd22dfba0cf8429f92925bff17de
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_89d90a2f0a3cec585a0dac12ceb3b95a |
| publicationDate |
2014-12-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2014377754-A1 |
| titleOfInvention |
Genomic Landscapes of Human Breast and Colorectal Cancers |
| abstract |
Human cancer is caused by the accumulation of mutations in oncogenes and tumor suppressor genes. To catalogue the genetic changes that occur during tumorigenesis, we isolated DNA from 11 breast and 11 colorectal tumors and determined the sequences of the genes in the Reference Sequence database in these samples. Based on analysis of exons representing 20,857 transcripts from 18,191 genes, we conclude that the genomic landscapes of breast and colorectal cancers are composed of a handful of commonly mutated gene “mountains” and a much larger number of gene “hills” that are mutated at low frequency. We describe statistical and bioinformatic tools that may help identify mutations with a role in tumorigenesis. These results have implications for understanding the nature and heterogeneity of human cancers and for using personal genomics for tumor diagnosis and therapy. |
| priorityDate |
2007-10-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |