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publicationDate 2014-12-25-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-2014377261-A1
titleOfInvention Vaccines against antigens involved in therapy resistance and methods of using same
abstract Methods of reducing the likelihood of a cancer or precancer developing resistance to a cancer therapeutic or prevention agent are provided herein. The methods include administering the cancer therapeutic or prevention agent and a vaccine comprising a polynucleotide encoding a polypeptide whose expression or activation is correlated with development of resistance of the cancer or precancer to the cancer therapeutic or prevention agent to a subject. The vaccine may include a polynucleotide encoding a HER3 polypeptide. Methods of using the vaccine including the polynucleotide encoding the HER3 polypeptide to treat a cancer or precancer are also provided.
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