| abstract |
The present invention provides a novel diazepine compound that blocks the I Kur current or the Kv1.5 channel potently and more selectively than other K + channels. The present invention relates to a diazepine compound represented by General Formula (1) n n n n n n n n n n n n or a salt thereof, n wherein R 1 , R 2 , R 3 , and R 4 are each independently hydrogen, lower alkyl, cyclo lower alkyl or lower alkoxy lower alkyl; n R 2 and R 3 may be linked to form lower alkylene; n A 1 is lower alkylene optionally substituted with one or more substituents selected from the group consisting of hydroxyl and oxo; n Y 1 and Y 2 are each independently —N═ or —CH═; n and n R 5 is group represented by n n n n n n n n n n n n n n n n wherein R 6 and R 7 are each independently hydrogen or organic group; n R 6 and R 7 may be linked to form a ring together with the neighboring group —X A —N—X B —; n X A and X B are each independently a bond, lower alkylene, etc. |