http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2014343227-A1
Outgoing Links
Predicate | Object |
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assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b09f893b262cefd50c5e76c4b85d1c0a |
classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C08F112-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K5-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K5-06086 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K1-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K1-062 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K1-068 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K17-08 |
classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08F112-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-06 |
filingDate | 2014-06-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f18b7854cb3d07140569503d7e534bb4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c535147c92167b764d973ad3fd868dd5 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ca25ced39e90538096f48fdb869f5150 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4876aa19d5f6c1a1aaa7a5bace9fa58c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_779b7a3468672732ced41acd8216f7d2 |
publicationDate | 2014-11-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber | US-2014343227-A1 |
titleOfInvention | Diketopiperazine Forming Dipeptidyl Linker |
abstract | The invention relates to a method for homogeneous solution phase peptide synthesis (HSPPS) of a N-terminal peptide fragment PEP-N and a C-terminal peptide fragment C-PEP, with C-PEP carrying a specific diketopiperazine (DKP) comprising C-terminal protecting group, which contains a handle group HG, with HG being connected to the C-terminus of the peptide fragmcnt; thereby this specific DKP comprising C-terminal protecting group can be selectively cleaved from the peptide as a conventionally used C-terminal protecting group. By the use of this DKP and HG comprising C-terminal protecting group, certain process steps in convergent peptide synthesis based on a combination of HSPPS and solid phase peptide synthesis (SPPS) can be avoided. The invention relates further to a method for the preparation of such specifically protected fragment C-PEP by SPPS by using a linker comprising a specific dipeptide and HG for connecting the growing peptide chain to the resin, which linker forms said DKP group, when the peptide fragment C-PEP is cleaved from the supporting resin; and further to the intermediates of the preparation method. |
priorityDate | 2010-10-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 652.