| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_18d92c46f60af8af24e262b67381d7eb |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2800-52 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-57415
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5011 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-50 |
| filingDate |
2014-05-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f772ba6fe7d8eead92cd69d4488d9341
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_60b244aa4ddf3ec5082d6cf8ad693d73 |
| publicationDate |
2014-11-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2014336282-A1 |
| titleOfInvention |
Molecular signatures of invasive cancer subpopulations |
| abstract |
Carcinomas typically invade as a cohesive multicellular unit, a process termed collective invasion. It remains unclear how different subpopulations of cancer cells contribute to this process. We developed three-dimensional (3D) organoid assays to identify the most invasive cancer cells in primary breast tumors. Collective invasion was led by specialized cancer cells that were defined by their expression of basal epithelial genes, such as cytokeratin-14 (K14) and p63. Furthermore, K14+ cells led collective invasion in the major human breast cancer subtypes. Importantly, lumenal cancer cells were observed to convert phenotypically to invasive leaders following induction of basal epithelial genes. Although only a minority of cells within lumenal tumors expressed basal epithelial genes, knockdown of either K14 or p63 was sufficient to block collective invasion. Our data reveal that heterotypic interactions between epithelial subpopulations are critical to collective invasion. We suggest that targeting the basal invasive program could limit metastatic progression. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108795872-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10781425-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113574164-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2017174609-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10174289-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11066650-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11767515-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3923984-A4
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2022160868-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3867354-A4
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11584916-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2020160628-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2017193021-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113627763-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11053477-B2 |
| priorityDate |
2013-05-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |