abstract |
Compounds according to formula I: n n n n n n n n n n wherein Ar is a fused aryl group, R 1 is selected from alkyl and aryl amides, CF 3 , and CH 2 OH, and R 2 is selected from hydrogen, —C(═O)CH 2 NH 2 , and —C(═O)CH 2 CH 2 NH 2 are described. The compounds are effective for inhibiting p21-activated kinases, and can be used for prevention and treatment of cancer. |