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publicationDate 2014-10-23-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-2014314783-A1
titleOfInvention Methods for suppressing allergic reactions
abstract Provided are methods for suppressing IgE and IgG-mediated allergic reactions through monoclonal antibody applications. More specifically, methods are herein provided for safe induction of rapid desensitization. Specific embodiments are herein provided for suppressing allergic reactions in a subject, including specific methods of providing a monoclonal antibody selected from the group consisting of anti-FcαRIa and anti-FcγRIIb/RIII; administering the antibody to a subject at a dose that is lower than the level required to induce shock; and administering sequentially escalating doses of the monoclonal antibody so as to induce rapid desensitization to an allergen, thereby suppressing allergic reaction in the subject.
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