| abstract |
The present invention relates to the use of avermectin derivative as a drug for the treatment of parasitic infections. The avermectin derivative is represented by the formula (I) wherein: (i) R 1 is chosen from the group constituted of —CH(CH 3 ) 2 , —CH(CH 3 )CH 2 CH 3 , or cyclohexyle, (ii) X represents —CH 2 CH 2 —, or —CH═CH—, (iii) R 2 is chosen from the group constituted of or —OH group, (iv) R 3 is OH or NOH, (v) represents a single bond when R 3 is OH, or a double bond when R 3 is NOH, as an inhibitor of a membrane-bound protein which transports exogenous compounds out of target cells. |