| abstract |
A method of inducing differentiation of mammalian cells into cardiomyocyte-like cells by contacting the mammalian cell with a triazine compound of formula (I), wherein X is independently —NR 4 — or —O—, R 4 is hydrogen or C 1-6 -alkyl; R 1 is hydroxy, C 1-6 -alkyl, C 1-6 -alkoxy, carboxy, C 1-6 -alkoxycarbonyl, halo, cyano, nitro, formyl, amino, C 1-6 -alkylamino, or di-C 1-6 -alkylamino, the C 1-6 -alkyl or -alkoxy residue being optionally substituted with one or more R 5 substituents selected from hydroxy, halo, cyano, and nitro; n is 0 to 5; R 2 is hydrogen, aryl, heteroaryl, or C 1-6 -alkyl, the aryl or heteroaryl residue being optionally substituted with one or more R 1 substituents, and where the C 1-6 -alkyl is optionally further substituted with one or more R 5 substituents; and R 3 is selected from hydrogen, halo, NR 4 R 7 , OR 7 , SR 7 , and R 7 , where the same options apply for R 7 as for R 2 ; with the proviso that the compound of formula (I) is not 3-[(4,6-diphenoxy-1,3,5-triazin-2-yl)amino]benzoic acid. |