http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2014228435-A1
Outgoing Links
Predicate | Object |
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assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_7008cc19142da8b252e06b717cf5a705 |
classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2800-78 |
classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K8-44 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C229-26 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-198 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-197 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61Q7-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C279-14 |
classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C229-26 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-197 |
filingDate | 2013-02-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_83b9eb04f1976facc10001245e34b86c |
publicationDate | 2014-08-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber | US-2014228435-A1 |
titleOfInvention | Composition and method of synthesizing a biomolecule and its therapeutics applications |
abstract | The embodiments herein provide a therapeutic composition comprising N (delta)-protonated L-2-amino-5-diaminomethyleneamino-pentanoic acid called J Factor and a method of ex-vivo synthesis of J-Factor from N(omega)′-protonated L-arginine at a pH of 5-9. The method involves increasing a temperature and or decreasing an acidity of an aqueous solution containing the N(omega)′-protonated L-arginine to obtain a pH value of greater than pKa−2 or less than pKa+2. The derivatives of aqueous solution are allowed to reach an equilibrium state at 25° C. The acidity of the acidity of the aqueous solution is adjusted to a pH value of 7.0 at 25° C. The pKa is a minus logarithm of an acid dissociation constant of the N(omega)′-protonated guanidino group. The N(omega)′-protonated 1-arginine includes ionized forms in the carboxyl or 2-amino group, which are in equilibrium with the N(omega)′-protonated 1-arginine. The composition has a molecular mass of more than or equal to 175.2u |
priorityDate | 2013-02-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 143.