abstract |
Provided are methods for treating cancer in a patient, comprising administering to a patient in need thereof a therapeutically effective regimen, the regimen comprising administering a gamma-secretase inhibitor, wherein the regimen results in a reduction in the cancer cell population in the patient. In some embodiments of the methods, the therapeutically effective regimen stabilizes, reduces or eliminates the cancer stem cell population. n Also provided are compounds of the formula I n n n n n n n n n n or a pharmaceutically acceptable salt thereof, wherein R 1 , R 2 , and X are as herein described. |