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publicationDate 2014-08-07-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-2014221614-A1
titleOfInvention Collagen matrix with locally controlled intrafibrillar and extrafibrillar mineral content and methods of producing
abstract A mineralized collagen matrix with an intrafibrillar and/or extrafibrillar gradient of mineralization for insertion replacement is disclosed. The intrafibrillar mineralization of the collagen matrix is formed by the addition of fetuin to the simulated body fluid. The gradient of intrafibrillar mineralization may stiffen the collagen matrix and simulate a natural insertion for improved cell infiltration and regeneration.
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