| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b2ed0c31857aa8d0b9c69478c34fcac1 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-19 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-18
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-19
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-1277
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-1278
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-127
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-1271
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-0019
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-5377
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-496
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-1275
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-07
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J13-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4196 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4196
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-496
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-07
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-127 |
| filingDate |
2014-02-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_beec3bff4bafa07e0d70808105abfba5
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ea5c6fe52ba5caab614a3b82c1ceb912
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_076567e03ec44f71b9fee04ec0087f54 |
| publicationDate |
2014-08-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2014220110-A1 |
| titleOfInvention |
Remote loading of sparingly water-soluble drugs into liposomes |
| abstract |
The present invention provides liposome compositions containing sparingly soluble drugs that are used to treat life-threatening diseases. A preferred method of encapsulating a drug inside a liposome is by remote or active loading. Remote loading of a drug into liposomes containing a transmembrane electrochemical gradient is initiated by co-mixing a liposome suspension with a solution of drug, whereby the neutral form of the compound freely enters the liposome and becomes electrostatically charged thereby preventing the reverse transfer out of the liposome. There is a continuous build-up of compound within the liposome interior until the electrochemical gradient is dissipated or all the drug is encapsulated in the liposome. However, this process as described in the literature has been limited to drugs that are freely soluble in aqueous solution or solubilized as a water-soluble complex. This invention describes compositions and methods for remote loading drugs with low water solubility (<2 mg/mL). In the preferred embodiment the drug in the solubilizing agent is mixed with the liposomes in aqueous suspension so that the concentration of solubilizing agent is lowered to below its capacity to completely solubilize the drug. This results in the drug precipitating but remote loading capability is retained. The process is scalable and, in liposomes in which the lipid composition and remote loading agent are optimized, the resulting drug-loaded liposomes are characterized by a high drug-to-lipid ratios and prolonged drug retention when the liposome encapsulated drug is administered to a subject. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2019209787-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11331272-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AU-2017308827-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2020232198-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11534399-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2016025611-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11583544-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-101730399-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2019358161-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-114832113-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10322192-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2020056102-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109562068-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2018031568-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2018200187-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10548986-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2017074475-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10004759-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2016220710-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11000478-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2021361576-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-114344303-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-112654348-A |
| priorityDate |
2013-02-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |