| abstract |
Provided is a 10-methoxycamptothecine derivate of formula (1), wherein R is selected from hydrogen, C 1-6 alkyl, C 1-6 haloalkyl, aryl substituted C 1-6 alkyl, phosphate substituted C 1-6 alkyl, amino-substituted C 1-6 alkyl, carboxyl substituted C 1-6 alkyl, hydroxyl substituted C 1-6 alkyl, and amide- substituted C 1-6 alkyl; R 1 is selected from hydrogen and t-butoxycarbonyl substituted amino. Also provided in the present invention are the preparation method of the derivate and the use thereof in anti-tumor drug preparation. |