http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2014178993-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ed9095d87b1e8774a32bedbe09f0907d |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K48-00 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-87 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-0067 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-0097 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-00 |
| filingDate | 2013-09-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_22641552633cde21e401dfc992f72879 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9ddcae0f51b1fddb59b5c2959b29e59b |
| publicationDate | 2014-06-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-2014178993-A1 |
| titleOfInvention | Method and applications of peptide-mediated mitochondrial delivery system |
| abstract | The present invention relates to a method using a cell penetrating peptide (Pep-1) for labeling and delivering mitochondria separated from healthy cells to replace damaged mitochondria. At present, microinjection of mitochondria into cells can only process one cell at a time, and therefore, this technique is limited to embryo related research and relevant applications. The advantages of the said peptide-mediated mitochondrial delivery system (PMD) include less steps with more efficiency, where a number of cells can be treated following one labeling process; the delivery process can be easily controlled, there is no cell toxicity after delivery under appropriate conditions, and delivery efficiency is over 80% depending on different cell types. Mitochondria delivered by the PMD system will move to the original mitochondrial location in the cells and will not be catalyzed in lysosomes; thus, the therapeutic effects can last at least one week. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-7185527-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2017124037-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3735976-A3 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AU-2017208013-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11491480-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10370458-B2 |
| priorityDate | 2011-12-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 44.