| abstract |
The invention relates to an oil-in-water adjuvant emulsion which comprises at least:n squalene, an aqueous solvent, a polyoxyethylene alkyl ether nonionic surfactant, a hydrophobic nonionic surfactant,n nwhich emulsion is thermoreversible, and wherein 90% of the population by volume of the oil drops has a size less than 200 nm.n nn The invention also relates to a process for preparing an immunogenic composition according to which at least one vaccine antigen is mixed with an oil-in-water emulsion, wherein the oil-in-water emulsion is obtained by means of a temperature-variation phase-inversion process. |