http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2014162271-A1
Outgoing Links
Predicate | Object |
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assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_079590112d6a0dcda517e9e2b337def7 |
classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2537-164 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2525-207 |
classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-1135 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6806 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-7088 |
classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-68 |
filingDate | 2013-06-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_65ec80c25de4d5b0e64eada68f112990 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_090ec16ae318e6cad1ffed68a28ccdd5 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_06e4c37950f0af2acafae46e61474902 |
publicationDate | 2014-06-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber | US-2014162271-A1 |
titleOfInvention | Methods of detecting long range chromosomal interactions |
abstract | The present invention relates to a method of monitoring epigenetic changes comprising monitoring changes in conditional long range chromosomal interactions at at least one chromosomal locus where the spectrum of long range interaction is associated with a specific physiological condition, the method comprising the steps of:—n (i) in vitro crosslinking of said long range chromosomal interactions present at the at least one chromosomal locus; (ii) isolating the cross linked DNA from said chromosomal locus; (iii) subjecting said cross linked DNA to restriction digestion with an enzyme that cuts at least once within the at least one chromosomal locus; (iv) ligating said cross linked cleaved DNA ends to form DNA loops; (v) identifying the presence of said DNA loops; wherein the presence of DNA loops indicates the presence of a specific long range chromosomal interaction. |
isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2023193382-A1 |
priorityDate | 2008-06-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 584.