Predicate |
Object |
assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_46d32171433fe0b21727f99facf19b5d http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_914cd6ba63feeeed196a5f79005f6747 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_7248ee8ffaeb1fa0db6efb0e4a9a555b http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e626cc8ca79bd190a7eba2d6b193ae97 |
classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-136 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-178 |
classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-1079 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5023 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6886 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6883 |
classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-50 |
filingDate |
2011-12-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7a4f37a8a2d9e7af136bae7948b7fc7f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_697ce4b962f55a5717b94b546f8d0afe http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f75243e294a17b43f1f7f1ac4fd79246 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_46bf423a35ca5b8f6f55e581a2fdac76 |
publicationDate |
2014-05-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber |
US-2014134635-A1 |
titleOfInvention |
RNAi-Based Method of Drug Screening and Characterization |
abstract |
The invention is directed to a method of characterizing a mechanism of action of an agent (e.g., a chemotherapeutic agent, a genotoxic agent). The method comprises contacting a plurality of populations of cells with an agent to be assessed, wherein each population of cells have one gene of interest targeted by a small hairpin RNA (shRNA) and wherein said gene of interest regulates cell death and a plurality of genes that regulate cell death are targeted in the plurality of populations of cells. A responsiveness of each population of cells to the agent is determined, thereby obtaining an shRNA signature of the agent, so as to identify one or more genes that mediate a response to the agent, thereby characterizing the mechanism of action of the agent. The invention is also directed an article of manufacture for characterizing a mechanism of action of a chemotherapeutic or genotoxic agent. |
isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2017350805-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10746647-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9670486-B2 |
priorityDate |
2010-12-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type |
http://data.epo.org/linked-data/def/patent/Publication |