| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b025939f539692788716c472bbe9b238
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a2f2c5972365172d35633c3e715a4137
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d296686100434d9e207cbf867d6b31ca
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_355192369c886170920ee656cf3b7d7f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_573adff39cbfb3e55fb1ea6608ce0940
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_9c05448d52a0c0b301f9393dc97e8cce |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K45-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-137
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-135
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-395
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4164
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-495
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-66 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-66
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-495
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K45-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4164
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-135 |
| filingDate |
2012-03-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1c88bf403691f506617aca7f6d3ed8d5
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_080b84115655b7977d580e93118c015c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a9931658f166965531bbd9f149318fbd
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8fb7a509ae979056990f3b3e947d67ee
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_41442c18c4b4be0f2780074530209df0 |
| publicationDate |
2014-04-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2014094444-A1 |
| titleOfInvention |
Compositions and methods for tissue engineering and cell based therapies |
| abstract |
The present application discloses strategies to recruit and mobilize stem cells using S1P receptor selective agonists and antagonists as wells as regulators of chemokine receptors. In an in vivo ischemic model, S1P 1 /S1P 3 activation with FTY720 impeded inflammatory cell infiltration and recruited endothelial progenitor cells (EPCs) with the potential to increase microvascular remodeling. S1P 3 expression on marrow-derived cells was essential for this remodeling. Concurrent systemic S1P 3 and CXCR4 antagonism mobilized hematopoietic stem cells (HSCs) with the ability to engraft and repopulate blood cells. Pre-treatment of donor HSCs with FTY720 increased homing toward SDF-1 and improved engraftment in marrow. FTY720-coated bone allografts coupled with systemic administration of VPC01091 enhanced bone allograft integration and new bone formation in bone defects. MSCs pre-treated with FTY720 exhibited increased migration toward SDF-1, a CXCR4+ ligand. The results show that S1P is a very powerful role player in pharmacological marrow-derived stem cell mobilization and recruitment. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9763980-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108653829-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2014193376-A1 |
| priorityDate |
2011-03-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |