Predicate |
Object |
assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f4f8755c361b70eb6af66fd6a114e590 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_37f4922dfb7777b019e504b885211b8e http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5293dea314be3370226bbbee0bc94994 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5ffc120c25aafa753a412f23e4508eab http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_89ad39789a8cdf5d55d90469913c13d0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_43a72884e25aaecffebe0942132d704f |
classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5023 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6897 |
classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-50 |
filingDate |
2012-04-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_70fdc75eb30f9d7a0be9f1f2aa909dfd http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f83350650c4548456170b7fd93c69c61 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a0b53d8ce4ca9139cf879d8ddf57d9e4 |
publicationDate |
2014-04-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber |
US-2014093884-A1 |
titleOfInvention |
Process for Identifying Novel Anti-Inflammatory Molecules with Reduced Direct Transrepression of Genes Induced by Glucocorticoids |
abstract |
The present invention relates to a new process for identifying novel anti-inflammatory molecules with reduced direct transrepression of genes induced by glucocorticoids. n The inventors have discovered that GCs-mediated transrepression can be mediated not only via the tethering indirect pathway, but also through direct binding of GR to “simple” negative GREs (nGRE), which belongs to a novel family of evolutionary-conserved cis-acting negative response elements (IR nGREs), and are found in numerous GC-repressed genes. |
isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2017190112-A1 |
priorityDate |
2011-04-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type |
http://data.epo.org/linked-data/def/patent/Publication |