| abstract |
The present application relates to methods for reducing growth of a fungus having a coordination complex formed at the C-terminus of its dicer (dicer 1, ribonuclease type III) between an anion and the amino acids corresponding to the amino acids C1275, H1312, C1350 and C1352 of Dcr1 of S. pombe (fission yeast) comprising the step of contacting a fungal cell with an effective amount of an agent, wherein said agent disrupts the coordination complex formed at the C-terminus of fungal dicer between an anion and the amino acids corresponding to the amino acids C1275, H1312, C1350 and C1352 of Dcr1 of S. pombe. |