| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_44886654ccfb545cb60477721382855c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_7f6205546f3c366820cb453160cf5d9c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_52f2e6de1c6f5a3ba7b48c7196e249b4
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f21c1009c60308a64b8e7dc0bb989632
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0432ac21467817296fe691e1ba8c2dad
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_4001d77d7a4031630206f330b7546f54
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d2aa040fc89c3b1b7c0f63027580e940 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-31
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K19-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-09
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-76
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-755
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-37 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-76
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-755 |
| filingDate |
2013-09-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3065bde9795ac442a93687198a53185b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0964468caa584b810752aa9fc812c16b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0f3432ebe8dfcae07a9f981fb11f4396
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_47fa8fafa043becfa65a28acc04bd95c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_175090a7be1ec26fb7f709b82f971dc3
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_391574fce0c6d64d21426d9eb19503f9 |
| publicationDate |
2014-03-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2014072561-A1 |
| titleOfInvention |
Factor viii, von willebrand factor or complexes thereof with prolonged in vivo half-life |
| abstract |
The present invention relates to modified nucleic acid sequences coding for coagulation factor VIII (FVIII) and for von Willebrand factor (VWF) as well as complexes thereof and their derivatives, recombinant expression vectors containing such nucleic acid sequences, host cells transformed with such recombinant expression vectors, recombinant polypeptides and derivatives coded for by said nucleic acid sequences which recombinant polypeptides and derivatives do have biological activities together with prolonged in vivo half-life and/or improved in vivo recovery compared to the unmodified wild-type protein. The invention also relates to corresponding FVIII sequences that result in improved expression yield. The present invention further relates to processes for the manufacture of such recombinant proteins and their derivatives. The invention also relates to a transfer vector for use in human gene therapy, which comprises such modified nucleic acid sequences. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-4089109-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11685771-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9758776-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11564976-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2016188905-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10772936-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10745680-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10421798-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10905747-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2017112895-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10370430-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9376672-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10548953-B2 |
| priorityDate |
2008-06-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |