| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f8c0982b0f02b1ed6d20a315370a3a3a |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-63
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-62
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-30
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-73
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-76
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-94
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-565
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-55
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-569
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2318-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-50
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-20
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-09
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-55
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-50
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-00 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-46
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-53
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-46
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-10 |
| filingDate |
2013-01-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a8bf99f61b62a4c97dd1b062695d40c2
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e1bddd3869b5e85670eed3758bf0996b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5221c680ed528c67709c76a99bc2ff28
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8da67a36d7832ae85cc264428b77b8ac
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_757c4c3b8563cbbb5ae642ecaa1d7d06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a36482464b5f8c5080ccc786b2c90b3b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_040f253eb76f29feafdca827c0f6b91e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_029ceb353801e937ddcea97c87d6c04c |
| publicationDate |
2014-02-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2014050720-A1 |
| titleOfInvention |
Ultralong complementarity determining regions and uses thereof |
| abstract |
Disclosed herein are immunoglobulin constructs comprising at least one immunoglobulin domain or fragment thereof; and a therapeutic polypeptide or derivative or variant thereof attached to or inserted into said immunoglobulin domain. Also provided are immunoglobulin constructs comprising a mammalian immunoglobulin heavy chain comprising at least a portion of a knob domain in the complementarity-determining region 3 (CDR3H) or fragment thereof; and a therapeutic polypeptide attached to or inserted into said knob domain of the CDR3H. Also provided are immunoglobulin constructs comprising a mammalian immunoglobulin heavy chain comprising at least a portion of a stalk domain in the complementarity-determining region 3 (CDR3H) or fragment thereof; and a therapeutic polypeptide attached to or inserted into said stalk domain of the CDR3H. Also described herein are methods and compositions comprising the immunoglobulin constructs described herein for treatment and prevention of a disease or condition in a subject. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10774132-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9981956-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10683353-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10562980-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9718865-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11390665-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10640574-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2016115218-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9663499-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11530493-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10259863-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11673959-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10336735-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2015191517-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9644021-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3155018-A4 |
| priorityDate |
2012-01-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |