http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2014050717-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_700ff9a01db2075489cb7ed87392dc28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_41a639aa11b9b2f8063a3e6b8b22b557 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-86 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-727 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-737 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K45-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-4846 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-4853 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-37 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-36 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-366 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K45-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-737 |
| filingDate | 2013-08-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_75d919cf0d09fcf3dbc882d8e1e675c7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_52e62d7a7d92bcfb5efba065a7d1600c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7a92a2e89edf491d8b1a5d2997e50189 |
| publicationDate | 2014-02-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-2014050717-A1 |
| titleOfInvention | Methods for Treating Bleeding Disorders |
| abstract | A method of factor X1-dependent blood coagulation enhancement in a subject in need of enhanced blood coagulation comprising administering a therapeutically effective amount of a composition comprising a non-anticoagulant sulfated polysaccharide (NASP) to the subject. A method of factor X1-dependent blood coagulation enhancement in a subject in need of enhanced blood coagulation comprising: (i) selecting a subject that is not deficient for factor X1; and (ii) administering a therapeutically effective amount of a composition comprising a non-anticoagulant sulfated polysaccharide (NASP) to the subject, wherein the NASP enhances blood coagulation in a factor X1-dependent manner. A method of identifying a non-anticoagulant sulfated polysaccharide (NASP) which is capable of enhancing blood coagulation in dependence on FXI, the method comprising: a) combining a blood or plasma sample comprising activation competent FXI with a composition comprising a sulfated polysaccharide and measuring the clotting or thrombin generation parameters of the blood or plasma sample; b) combining a corresponding blood or plasma sample deficient in activation competent FXI with a composition comprising the sulfated polysaccharide and measuring the clotting or thrombin generation parameters of the blood or plasma sample; and c) comparing the clotting or thrombin generation parameters of the blood or plasma samples as determined in steps (a) and (b) with each other, wherein a decrease in the clotting time of the blood sample or an increase in peak thrombin or decrease in peak time of the plasma sample comprising activation competent FXI compared to the clotting time of the blood sample or peak thrombin or peak time of the plasma sample deficient in activation competent FXI is indicative of a NASP which is capable of enhancing blood coagulation in dependence on FXI. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11565002-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11081211-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9687529-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11670409-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10889816-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11783931-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10660973-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10896749-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11749394-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9873727-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2014275226-A1 |
| priorityDate | 2008-08-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 394.