http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2014039204-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b498609526ef5ab1a7239ddf072a9ab7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5e06bbf2a93ce8414011cb5ba011faf8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a7bc5e950f27bf5979a7115615635705 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K8-498 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K8-49 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K8-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61Q7-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61Q7-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K8-49 |
| filingDate | 2011-03-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d5a66e2efd7ce65b21e3d9d95de3ac14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_958ce18e43e341129fc231e9ccadc0b3 |
| publicationDate | 2014-02-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-2014039204-A1 |
| titleOfInvention | 7'-phloroeckol compound for hair proliferation and a cosmetic composition containing same |
| abstract | The effects on human hair growth of 7′-phloroeckol (1-(3′,5′-dihydroxyphenoxy)-7-(2″,4″,6-trihydroxyphenoxy)-2,4,9-trihydroxydibenzo-1,4-dioxin) isolated from E. cava ( Ecklonia cava ) have been studied in cell systems. The cell-proliferation and anti-apoptotic effects on human human hair follicle dermal papilla cells (HFDPC) and human keratinocytes (human epidermal keratinocytes: HaCaT) were investigated using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay and western blot. The 7′-phloroeckol significantly increased HFDPC and HaCaT proliferation. With HFDPC and HaCaT, the amount of PI3K and phosphorylated AKT protein expression increased in a way which was dependent on the extent of 7′-phloroeckol treatment. Also, the levels of MEK½, phosphorylated ERK and c-Fos proteins, which are associated with cell proliferation, increased in a way which was dependent on the extent of 7′-phloroeckol treatment. Meanwhile, apoptosis was inhibited as there was an increase in the Bcl-2/Bax ratio which is associated with apoptosis, and there was a significant reduction in p53 and also caspase-3 and caspase-9. These results indicate that 7′-phloroeckol can promote human hair growth by inhibiting apoptosis and stimulating HFDPC and HaCaT proliferation. |
| priorityDate | 2011-01-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 256.