http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2014024611-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_cb8f3eba86915d967beefc175437273a http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a722744e77c81c5f5cf415087e2ee92b |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H19-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H19-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H19-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H19-24 |
| filingDate | 2013-05-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b84fedb25957c239039743f0734c3cd9 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_aa1e590206e6b3e9a2a0d1703e2ecdee http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a02c7a6549eafd2db5527f5896ca97b3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e2aed99edcf9e87607bdad232ae9279f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1ea6c85461c3d7d40bae852532188e0a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0d3851ad62e076186fbb1ff0f59bf82e |
| publicationDate | 2014-01-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-2014024611-A1 |
| titleOfInvention | Anti-microbial agents and uses thereof |
| abstract | Many pathogens, including Mycobacterium tuberculosis and Yersinia pestis , rely on an iron acquisition system based on siderophores, secreted iron-chelating compounds with extremely high Fe(III) affinity. The compounds of the invention are inhibitors of domain salicylation enzymes, which catalyze the salicylation of an aroyl carrier protein (ArCP) domain to form a salicyl-ArCP domain thioester intermediate via a two-step reaction. The compounds include the intermediate mimic 5′-O—[N-(salicyl)sulfamoyl]-adenosine (salicyl-AMS) and analogs thereof. These compounds are inhibitors of the salicylate activity of MbtA, YbtE, PchD, and other domain salicylation enzymes involved in the biosynthesis of siderophores. Therefore, these compounds may be used in the treatment of infection caused by microorganisms which rely on siderphore-based iron acquisition systems. Pharmaceutical composition and methods of using these compounds to treat or prevent infection are also provided as well as methods of preparing the inventive compounds. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2015176732-A1 |
| priorityDate | 2005-04-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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