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publicationDate 2014-01-02-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-2014005374-A1
titleOfInvention Chimeric oligomeric compounds for modulation of splicing
abstract Disclosed herein are compounds, compositions and methods for modulating splicing of a selected target mRNA. Further provided are uses of the disclosed compounds and compositions in the manufacture of a medicament for treatment of diseases and disorders. Methods of enhancing cellular uptake, modulating tissue distribution and enhancing pharmacological activity of RNase H-independent antisense oligonucleotides are also provided.
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