| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_bc2b03342511abc88f60c63f2acd96d0 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-0032
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-0054
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-0093 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K49-00 |
| filingDate |
2013-06-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_afcd55c0b26771791b102351e8de450a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4651730c06fc4c5e095d9259c3bc02f2
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6c78486c93a910a8ef373e6861594859 |
| publicationDate |
2014-01-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2014004049-A1 |
| titleOfInvention |
Nanoprobes for sensing of reactive oxygen and reactive nitrogen species |
| abstract |
For whole animal in-situ and real-time imaging of inflammation, a dual-color fluorescent nanoprobe is provided for the detection of reactive oxygen and nitrogen species (RONS) in inflammatory microenvironments. The nanoprobes of the disclosure are a RONS-responsive energy transferring nanosystem of a fluorescent conjugated polymer core and a PEG-shell linked with RONS-sensing antennae as a FRET acceptor. These nanoprobes allow in vivo imaging of the entire process of inflammation from the release of local tissue distress signals, to the action of leukocytes and macrophages late in the process of inflammation, through to restitution, allowing in whole-body diagnosis and monitoring of inflammatory diseases. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10502733-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11391728-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2016075481-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2018011086-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2016191985-A1 |
| priorityDate |
2012-06-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |