http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2013331330-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_bc2b03342511abc88f60c63f2acd96d0 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-164 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-7088 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-7088 |
| filingDate | 2013-06-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a982b152beec9879abed527f564ebf2c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2e72af8253455c15f0d0e07e348f6d66 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b27b1418fcfae131a85d16986f32fa1e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_736f09c26decb214fad75b0715ef9298 |
| publicationDate | 2013-12-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-2013331330-A1 |
| titleOfInvention | Methods of treating alzheimer's disease and other tauopathies with inhibitors of microtubule affinity regulating kinase |
| abstract | Methods of treating Alzheimer's disease and other tauopathies are disclosed. In particular, the invention relates to methods of treating Alzheimer's disease and other tauopathies with inhibitors of microtubule affinity regulating kinase (MARK). Hyperphosphorylation of tau by MARK is associated with the pathogenic deposition of intracellular neurofibrillary tangles and loss of synaptic markers, dendritic spines, and synapses during progression of Alzheimer's disease and other tauopathies. Peptide inhibitors derived from the Helicobacter pylori protein CagA block phosphorylation of tau in neuronal cells and thereby decrease the deposition of neurofibrillary tangles and the toxic effects of Abeta-42. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2017087467-A1 |
| priorityDate | 2012-06-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 1327.