| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8b659f9c2985abbc2b4176b0c9ada364
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_67348e80030cdde59429baa7113f8365
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1779c4ab7133b0c4994a0604bc4d8b22
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_84bf44a22dde8c992264d73e5394ea65
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_fdbcd91afe222be9465f712aaa12d7ee
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_be6e705e5c53ed743e26d81d24cc824f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_9c2a8e8021fc9722331aa4543dbd8789 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2800-2835
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2800-30
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-33
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-34
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2800-387
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2800-302
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2800-2814
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2800-2821
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-70 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-18
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-54306
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-6896
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-18
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-0004
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K51-1018 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-18 |
| filingDate |
2013-08-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6eddd048cc479be662c37ce86ad53739
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f033142a24de55f5e94afd6df2bb209b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_93eba67b1b2e458bebe9d365712f15f3
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a6ae47a1fac1f5e814f3feb5868a97cb
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_70b4a3757fc9ef5650abbacc02eb12c3
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ff3eb77c967857e12a8d983349eafe67 |
| publicationDate |
2013-11-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2013309251-A1 |
| titleOfInvention |
Protofibril-Binding Antibodies And Their Use In Therapeutic And Diagnostic Methods For Parkinson's Disease, Dementia With Lewy Bodies And Other Alpha-Synucleinopathies |
| abstract |
Antibodies and fragments thereof have high affinity for human α-synuclein protofibrils and low binding of α-synuclein monomers, wherein the antibodies or fragments have specified Complementarity Determining Region (CDR) sequences. Compositions comprise such an antibody or fragment and methods of detecting α-synuclein protofibrils use such an antibody or fragment. In further embodiments, methods of preventing, delaying onset of or treating a neurodegenerative disorder with α-synuclein pathology comprise administering such an antibody or fragment, and such an antibody or fragment is used in the manufacture of a pharmaceutical composition for treatment of a neurodegenerative disorder with α-synuclein pathology. Such an antibody or fragment is used in the diagnosis or monitoring of the development of a neurodegenerative disorder with α-synuclein pathology, and in methods for reducing or inhibiting α-synuclein aggregation by administration of such an antibody or fragment. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2019126395-A1 |
| priorityDate |
2010-02-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |