| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_04994d36363c5edee14e3b13292fb2db
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3d1b34e3b36db3ea34c4c65ebecb04ff
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_4d266f8515a33e37fa9c89bae66524c4 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2513-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2500-90
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K35-30
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2533-80 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0621 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-071 |
| filingDate |
2012-05-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7130bb6c133642dea629edd49c86f2a2
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9e103a290e8c39c4472f143f21509b1e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c4a4274286f727d4f38fda4dd171efea |
| publicationDate |
2013-11-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2013302885-A1 |
| titleOfInvention |
Method of Forming Cell Spheroids Cultured in Serum-Free Manner on Nanoscale Coatings of Hyaluronic Acid with High Molecular Weight |
| abstract |
A method of forming cell spheroids cultured in a serum-free manner on nanoscale coatings of hyaluronic acid with high molecular weight is disclosed. Corneal stromal cells are cultured on the hyaluronic acid coatings with nanotopography in the serum-free manner. Experimental results show that the cells cultured on the hyaluronic acid coatings (1.1-1.7 nm) increase cell-cell interaction, and when the cells form three-dimensional spheroids, they have higher biological synthetic capabilities and can secret more extracellular matrix, which has potential applications in corneal stromal tissue reconstruction. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2020283736-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2015116990-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10307760-B2 |
| priorityDate |
2012-05-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |