| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2b16bb68a809ced2262eaa7758b1d58e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_7b9bf983681da443f0e1b2336f26f630
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_59a64c96b008aa6505548acb3cc0fa68
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_eb1145753f015de2f4f0bcc1554a72e7 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K45-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K35-766
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-366
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-437 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K35-766
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K35-76
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-366
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K45-06 |
| filingDate |
2011-11-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_482060d608dcb97761f6c1df1a5fb8ed
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4f18803dc0e564228c9787a617bf8e52
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c0870e8e7477ce9b99c72db0b20eeb99 |
| publicationDate |
2013-11-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2013302284-A1 |
| titleOfInvention |
Modulating oncolytic vsv and upregulating rae1 and nup98 with statins |
| abstract |
Simvastatin is used to modulate VSV infection at the level of viral replication. Both lipid-lowering and pleiotropic cellular effects of simvastatin are exploited in the modulation. Simvastatin upregulates the expression of Rae1 and Nup98, therefore altering normal cellular mRNA distribution and reverting VSV's mRNA export block. Furthermore, simvastatin causes redistribution of Flotillin-1, which affects VSV replication/budding. Simvastatin is further used as a neoadjuvant for the selective modulatory control of live VSV oncolytic therapy. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9289456-B2 |
| priorityDate |
2010-11-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |