| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a755dadfd2e3b2c88c16e85ece5edc13
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_9c2ba9269b13ec4d082fa73d9f17b2ca
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ada79c3f1a30d1b14919e90a1ab08930
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c3ec5c4f8fa5883e0f84fcc6d2ac3a82
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ff833830afb95073e8fcd0d442785419 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B82Y40-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-146
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61J3-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61J3-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-343
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B05D7-24
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-5161
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-5138
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-216 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61J3-00 |
| filingDate |
2013-03-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8954ad3ff48c50413615419ba18f91a6
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_33eb0461d585736d287d4dc7dec90c58
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b78490fe8645290d88ca2c946ad6a827
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e55cbd6154a7facb9fdd8eb65407f975 |
| publicationDate |
2013-11-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2013295190-A1 |
| titleOfInvention |
Systems and Methods for Superdisintegrant-Based Composite Particles for Dispersion and Dissolution of Agents |
| abstract |
The present disclosure provides improved systems and methods utilizing colloidal/ultrafine superdisintegrant-based composite particles for dispersion and/or dissolution of active pharmaceutical agents. In general, the present disclosure utilizes a surfactant-free or near surfactant-free formulation by incorporating a wet milled SDI as a dispersant in the formulation. As such, the present disclosure provides for the preparation of surfactant-free or substantially surfactant-free formulations (e.g., nano-composite micro-particle formulations) by incorporating a wet-milled superdisintegrant (SDI) as the dispersant in the formulations. The advantageous SDI particles (e.g., colloidal/ultrafine SDI particles) of the present disclosure can be used to break-up the aggregates (e.g., nanoparticle aggregates) of the active agents (e.g. poorly water-soluble drugs) in the formulations (e.g., micro-particle formulations) and enhance the recovery of the nanoparticles of active agents during aqueous re-dispersion and their dissolution rate in vitro and in vivo. |
| priorityDate |
2012-04-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |