| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8a77c084abd5af7cd00fb755225380dc
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c648f1f5c4e78e346f7402adbbc57568
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c98b1513e8f9e30e2ec40a27e62a0240
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_7f983f7bba88a5b7a1b6fe9e18ea2e1f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f9628658ef0edd39c9b17fe4affb64b3 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-225
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-37
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D311-16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-095 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-37
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-10 |
| filingDate |
2012-06-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_65830b88005284a162746254d48b45f4
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c24f6f58c7197f9cda6dcc51af7716fc
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_01c79f8c78d7f35d59792103175618c8
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2e0d70e151364fe9c24c032d7297aac3 |
| publicationDate |
2013-10-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2013289104-A1 |
| titleOfInvention |
Aliphatic amino acid biosynthesis inhibitors and a method of synthesizing the same |
| abstract |
The embodiments herein provide a composition and a method of synthesizing a composition comprising an aliphatic amino acid biosynthesis inhibitor having an antifungal activity. The composition comprises 2-oxo-2H-chromen-7-yl propiolate, diethyl-hex-2-en-4-yne-dioate and dinonyl-hex-2-en-4-yne-dioate. The composition inhibits a biosynthesis of an aliphatic amino acid in a fungal biological system. The aliphatic amino acid is selected from a group consisting of leucine, isoleucine and valine. The composition is used with a concentration of 0-200 μg/ml. The method comprises mixing solutions of dicyclohexylcarbodiimide (DCC) and Dimethylaminopyridine (DMAP) with alcohol, acetylene carboxylic acid and dichloromethane to obtain a mixture which is stirred filtered and washed with ether. The solvents are evaporated to obtain a residue that is dissolved in dichloromethane and stirred with a catalyst. The extra solvents are evaporated to obtain the derivative compound and purified by silica gel column chromatography. |
| priorityDate |
2012-04-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |