| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a84a77ff369b0711477b28dfe2f20016
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c66f1553ae03350503caba7cd466c2a7
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_657011521cc210bd2be5a9ffea7bd48c |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-7088
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-7105
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-711
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-5089
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-1272
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-1278
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-127 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-127
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-50
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-7088 |
| filingDate |
2013-03-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_532bf6e9bfb0ea235e57470048e95a47
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c876d61f5e859d8998a92de6ad264489
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1e7ccff5c6dd54fbff1c764ad5557f38 |
| publicationDate |
2013-10-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2013273146-A1 |
| titleOfInvention |
Methods for preparation of lipid-encapsulated therapeutic agents |
| abstract |
Fully lipid-encapsulated therapeutic agent particles of a charged therapeutic agent are prepared by combining a lipid composition containing preformed lipid vesicles, a charged therapeutic agent, and a destabilizing agent to form a mixture of preformed vesicles and therapeutic agent in a destabilizing solvent. The destabilizing solvent is effective to destabilize the membrane of the preformed lipid vesicles without disrupting the vesicles. The resulting mixture is incubated for a period of time sufficient to allow the encapsulation of the therapeutic agent within the preformed lipid vesicles. The destabilizing agent is then removed to yield fully lipid-encapsulated therapeutic agent particles. The preformed lipid vesicles comprise a charged lipid which has a charge which is opposite to the charge of the charged therapeutic agent and a modified lipid having a steric barrier moiety for control of aggregation. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2017143630-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10369104-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11337924-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2019035947-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9956176-B2 |
| priorityDate |
1999-07-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |