http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2013267731-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_85ee29d887b408e5100e60124873b1b7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e5c7e8e425df4dfb7c99458081f6506e http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ab38ba3d8884e3c8dccc0171dbb872ce http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_10bd7baf82e51a4b37e0e24ee06d11ef |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F9-3873 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-02 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F9-38 |
| filingDate | 2011-09-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8d62a6299f02ace029c73e19c8976a71 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3c89c1391a1aca24f067e6fca7c52114 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d163308ddd88b6496a7c04d80638ae0c |
| publicationDate | 2013-10-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-2013267731-A1 |
| titleOfInvention | Tripodal Bisphosphonate Derivatives |
| abstract | The present invention describes tripodal bisphosphonate derivatives with a flexible basic framework for the functionalisation of surfaces, and methods for their production and use. The central atom of the flexible framework is hereby a tertiary aliphatic carbon atom. A fourth remaining position of the flexible framework is suitable to be optionally functionalised by so-called click reactions, for example with biomolecules, polyethylene glycol or active agents. n The compounds according to the present invention have the general formula X—C{(CH 2 ) n —Y—C[PO(OH) 2 ] 2 R 1 } 3 , wherein X stands for a group —(CH 2 ) p —R 3 , wherein p=0 to 10 and R 3 is selected from —H, —NH 2 , —NO 2 , —OH, —SH, —O—NH 2 , —NH—NH 2 , —N═C═S—, —N═C═O—, —CH═CH 2 , —C≡CH, —COOH, —(C═O)H, —(C═O)R 4 Y stands for —CH 2 —, —CH═CH—, —C≡C—, —O—, —S—, —S—S—, —NH—, —O—NH—, —NH—O—, —HC═N—O—, —O—N═CH—, —NR 2 —, -aryl-, -heteroaryl-, —(C═O)—, —O—(C═O)—, —(C═O)—O—, —NH—(C═O)—, —(C═O)—NH—, —NR 2 —(C═O)—, —(C═O)—NR 2 —, —NH—(C═O)—NH—, —NH—(C═S)—NH—, R 1 represents a hydrogen atom or a hydroxy group, R 2 stands for a linear or branched alkyl group and R 4 for a linear or branched alkyl group or an aryl group. The production of the compounds occurs by reacting a compound X—C[(CH 2 ) n —Y′] 3 with a reagent Y″C[PO(OH) 2 ] 2 R 1 to the corresponding compound X—C{(CH 2 ) n —Y—C[PO(OH) 2 ] 2 R 1 } 3 and subsequent purification of the reaction product. Y′ and Y″ are hereby precursors of Y. The compounds according to formula (I) according to the present invention are suitable to be used in a method to functionalise surfaces. The X group of the compounds according to the present invention is suitable to be optionally coupled to an effector, for example, by means of click chemistry. |
| priorityDate | 2010-09-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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