| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_81ad53b64eb74859acdc01278829b080 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-6854 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-68 |
| filingDate |
2013-03-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_66cc87061487cab00ae1de196919a322
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fc297b7d411ca1abcbdb64ea5a171ba7 |
| publicationDate |
2013-10-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2013266963-A1 |
| titleOfInvention |
Assay for detecting neutralizing autoantibodies to biologic therapy |
| abstract |
The present invention provides assays for detecting and measuring the presence or level of neutralizing and non-neutralizing autoantibodies to biologics such as anti-TNFα drug therapeutics in a sample. The present invention is useful for monitoring the formation of neutralizing and/or non-neutralizing anti-drug antibodies over time while a subject is on biologic therapy. The present invention is also useful for predicting and/or determining the cross-reactivity of neutralizing anti-drug antibodies in a subject's sample with alternative biologic therapies. As such, the present invention provides information for guiding treatment decisions for those subjects receiving therapy with a biologic agent and improves the accuracy of optimizing therapy, reducing toxicity, and/or monitoring the efficacy of therapeutic treatment to biologic therapy. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2016536587-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9465027-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10794906-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2020214528-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AU-2014342316-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8865417-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9784748-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-105765386-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10775386-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109791142-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9506920-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2018074073-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11709166-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10386366-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10261094-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3063543-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10422807-B2 |
| priorityDate |
2011-07-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |